Drug intelligence / Profile preview

newbouldia laevis leaf extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Newbouldia laevis leaf extract is a botanical preparation derived from the leaves of the Newbouldia laevis tree, a species native to tropical Africa and commonly known as the African border tree. In traditional Nigerian medicine, the extract is utilized for its purported analgesic, anti-inflammatory, and anticonvulsant properties, particularly in the management of pain, inflammatory conditions, convulsions, and epilepsy. Scientific studies in animal models, such as Wistar rats, have provided evidence supporting these ethnomedicinal claims, demonstrating significant activity in reducing pain perception and seizure frequency. The pharmacological effects are attributed to a complex mixture of phytochemicals, including flavonoids, alkaloids, tannins, and saponins, which are thought to modulate inflammatory pathways and neurotransmitter systems in the central nervous system.

Other names
Newbouldia laevis leaves extractAfrican border tree leaf extractBoundary tree leaf extractOgirisi leaf extractAkoko leaf extract
02

Targets

AMY (Pancreatic alpha-amylase)

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