NEXCHANGE KIT

**NEXCHANGE KIT** is an investigational, fixed-combination drug-device product from Osteal Therapeutics for treatment of hip or knee periprosthetic joint infection during two-stage exchange arthroplasty. The kit uses a spacer, wound-fluid management components, and an irrigation system to cyclically administer high local concentrations of **vancomycin** and **tobramycin** into the infected joint space over approximately seven days before permanent-prosthesis reimplantation. Vancomycin inhibits bacterial cell-wall synthesis by binding peptidoglycan precursor termini, while tobramycin binds bacterial 30S ribosomes and disrupts protein synthesis. NEXCHANGE KIT remains investigational and is not FDA approved. ([ostealtx.com](https://www.ostealtx.com/nexchange))

Brand names

NEXCHANGENEXCHANGE KIT

Other names

VT-X7 KITVT-X-7 KITVT-X 7 KIT