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NG-641
- Development stage
- Phase 1
- Lead developer
- Akamis Bio
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous, Intratumoral
01
Overview
NG-641 is an experimental oncolytic adenoviral vector engineered to selectively infect and replicate in tumor cells. It encodes four immunostimulatory transgenes: a fibroblast activation protein (FAP)-directed bispecific T-cell activator antibody (FAP-TAc), interferon alpha (IFNα), and the chemokines CXCL9 and CXCL10. The FAP-targeted bispecific antibody redirects T cells to attack cancer-associated fibroblasts within the tumor microenvironment, while IFNα and the chemokines enhance immune cell recruitment and activation. This multi-pronged approach aims to remodel the tumor microenvironment for improved anti-tumor immunity. Developed by Akamis Bio (formerly PsiOxus Therapeutics), NG-641 is being investigated primarily for solid tumors including squamous cell carcinoma of the head and neck in early-phase clinical trials[1][2][3][4][5][6][7][8].
- Other names
- enadenotucirev-expressing FAP/CD3 bispecific FAP-TAc NG-641
02
Targets
CD3 (T-cell surface glycoprotein CD3)CCR3 (C-C chemokine receptor type 3)FAP (Fibroblast activation protein alpha)IFNAR (Immune system modulation via type I interferon receptor)CXCL10 (C-X-C Motif Chemokine Ligand 10)CXCL9 (C-X-C motif chemokine ligand 9)IFN-α (Interferon alpha-7)
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