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NG-Shield is an AI-designed prophylactic vaccine candidate developed by Evaxion Biotech for the prevention of *Neisseria gonorrhoeae* infections. The vaccine was discovered using Evaxion's proprietary EDEN (Epitope Discovery ENgine) platform, which utilizes artificial intelligence to identify highly conserved and protective antigens from the bacterial proteome. By targeting multiple computationally selected antigens, NG-Shield aims to provide broad protection against diverse strains of gonorrhea, including multi-drug resistant (MDR) 'super-gonorrhea' strains. The program is currently in the preclinical development stage, representing a novel approach to addressing the global health threat posed by the increasing prevalence of antibiotic-resistant *Neisseria gonorrhoeae*.
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