NGO1549

**NGO1549**, also known as FtsN, is a recombinant protein antigen derived from *Neisseria gonorrhoeae*, functioning as a cell division protein essential for bacterial viability and part of the gonococcal divisome interactome. It interacts with other cell division proteins like FtsK and FtsA. Identified via AI-driven platforms such as EDEN and immunobioinformatics, it elicits systemic IgG antibodies that support complement-dependent bactericidal activity against multiple gonococcal strains, including multidrug-resistant isolates like WHO X (H041). In preclinical mouse vaginal colonization models, immunization with NGO1549 alone or combined with NGO0265 significantly reduces bacterial burden and accelerates clearance in a complement-dependent manner (requiring C5b-9 membrane attack complex), positioning it as a promising lead candidate for a gonococcal vaccine.

Other names

FtsN