Drug intelligence / Profile preview

NIA24

Development stage
Discontinued
Lead developer
Niadyne Pharma
Modality
Small Molecules
Administration
Topical
01

Overview

NIA24 is a topical cosmeceutical skincare line developed by Niadyne Pharma (Niadyne Inc.) based on over 25 years of biomedical research. The core technology is Pro-Niacin (myristyl nicotinate), a proprietary, lipophilic derivative of niacin (vitamin B3) designed to penetrate the skin barrier and deliver nicotinic acid to the deeper layers of the skin via a micronutrient delivery system. Once absorbed, Pro-Niacin converts to nicotinamide adenine dinucleotide (NAD), which stimulates DNA repair by activating PARP (poly-ADP-ribose polymerase) and enhances energy metabolism within skin cells. The technology also targets the niacin receptor (HCAR2/GPR109A) to strengthen the skin's natural barrier and improve overall skin texture. NIA24 was marketed for consumer indications including photodamage, hyperpigmentation, fine lines, and wrinkles, though the brand has reportedly been discontinued.

Brand names
NIA24NIA-24NIA 24
Other names
Pro-Niacinmyristyl nicotinate
02

Targets

HCAR2 (Hydroxycarboxylic acid receptor 2)

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