Drug intelligence / Profile preview

Niacinamide Brightening Toner

Development stage
Phase 3
Lead developer
Good Molecules
Modality
Small Molecules
Administration
Topical
01

Overview

Niacinamide Brightening Toner is a topical skincare product developed by Good Molecules to address uneven skin tone, dullness, and visible pores. The formulation features a combination of active ingredients including niacinamide (vitamin B3), arbutin, licorice root extract, and 3-O-ethyl ascorbic acid (a stable vitamin C derivative). Niacinamide works by inhibiting the transfer of melanosomes from melanocytes to keratinocytes, while arbutin and licorice root extract act as tyrosinase inhibitors to reduce melanin synthesis. In clinical research, specifically a Phase 3 study (NCT05486130), the toner was evaluated as an adjunctive treatment used in combination with prescription-strength 4% hydroquinone to improve the appearance of facial hyperpigmentation and melasma.

Brand names
Niacinamide Brightening Toner
Other names
Good Molecules Facial TonerBrightening Toner
02

Targets

TYR (Tyrosinase)

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