nialamide

Nialamide is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) of the hydrazine class that was previously used as an antidepressant. It acts by inhibiting both monoamine oxidase A (MAOA) and monoamine oxidase B (MAOB), enzymes responsible for the breakdown of neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. This inhibition leads to increased levels of these neurotransmitters and an antidepressant effect. Nialamide was developed by Pfizer but was withdrawn from clinical use in the 1960s due to risks of hepatotoxicity and dangerous interactions with tyramine-containing foods that could cause hypertensive crises. It has also been studied for anti-tuberculosis activity and more recently as a potential antiviral agent in combination therapies[1][3][4][5][6].

Brand names

NiamidNiamideNuredalSurgex

Other names

nialamide