nicotinamide-adenine-dinucleotide-5-hydroxy-4-oxonorvaline

Nicotinamide-adenine-dinucleotide-5-hydroxy-4-oxonorvaline is an experimental small molecule that belongs to the class of (5'->5') dinucleotides. It is a synthetic analog of nicotinamide adenine dinucleotide (NAD) in which the molecule 5-hydroxy-4-oxonorvaline (HON) forms a covalent adduct with NAD at the C4 position of the nicotinamide ring and C5 of HON. This compound has been studied primarily for its antifungal properties, where it acts as a potent inhibitor of homoserine dehydrogenase by forming this enzyme-dependent covalent adduct, leading to antifungal activity despite weak steady-state inhibition. There are no approved indications or clinical trials for this compound; it remains an experimental agent used in biochemical and structural studies[1][2].

Other names

nicotinamide-adenine-dinucleotide-5-hydroxy-4-oxonorvalinenicotinamide-adenine-dinucleotide5-hydroxy-4-oxonorvalinenicotinamide-adenine-dinucleotide 5-hydroxy-4-oxonorvaline