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nicotinamide N-methyltransferase antisense oligonucleotide
- Development stage
- Preclinical
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Oral, Intravenous, Subcutaneous
01
Overview
A nicotinamide N-methyltransferase antisense oligonucleotide is a therapeutic agent designed to inhibit the enzyme nicotinamide N-methyltransferase (NNMT). NNMT plays a crucial role in metabolism by methylating nicotinamide, a precursor to NAD+. Inhibition of NNMT leads to increased levels of S-adenosylmethionine (SAM) and NAD+ in adipose tissue, and upregulates the activity and expression of ornithine decarboxylase (ODC) and spermidine-spermine N(1)-acetyltransferase (SSAT). This results in increased polyamine flux and enhanced oxygen consumption in adipocytes. Furthermore, NNMT inhibition influences histone H3 lysine 4 methylation. This mechanism suggests its potential as a treatment for obesity and type 2 diabetes by augmenting cellular energy expenditure.
- Other names
- NNMT antisense oligonucleotideantisense oligonucleotide targeting nicotinamide N-methyltransferase
02
Targets
NNMT (Nicotinamide N-methyltransferase)
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