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Nicotinamide riboside is a derivative of vitamin B3 (niacin) and serves as a precursor to nicotinamide adenine dinucleotide (NAD+), an essential coenzyme involved in cellular energy metabolism. Upon oral administration, it increases NAD+ levels in cells and tissues, which can activate sirtuin enzymes such as SIRT1 and SIRT3. These effects are associated with enhanced oxidative metabolism, improved mitochondrial function, neuroprotection in models of neurodegenerative disease (such as Alzheimer's disease), and potential benefits for metabolic health including protection against diet-induced metabolic abnormalities. Nicotinamide riboside is used primarily as a dietary supplement for its purported anti-aging properties and support of cellular energy production[1][2][4][6].
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