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nicotinamide riboside + zinc
- Development stage
- Unknown
- Lead developer
- Cedars-Sinai
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Nicotinamide riboside + zinc is an investigational combination therapy consisting of two dietary supplements being evaluated by Cedars-Sinai Medical Center for the treatment of idiopathic pulmonary fibrosis (IPF). The therapy targets the ZIP8/SIRT1/NAD+ pathway to promote lung tissue regeneration and mitigate scarring. Nicotinamide riboside, a form of vitamin B3, serves as a precursor to nicotinamide adenine dinucleotide (NAD+), which is essential for DNA repair and mitochondrial function. Zinc is included to restore the function of ZIP8, a zinc transporter that is often downregulated in IPF, thereby aiding the regenerative potential of type 2 alveolar epithelial cells (lung stem cells). This combination is currently being studied in a decentralized Phase 2 clinical trial (NCT06567717) to assess its feasibility and efficacy in improving lung function and symptoms.
- Other names
- Zinc and Nicotinamide Riboside
02
Targets
SIRT1 (NAD-dependent protein deacetylase sirtuin-1)ZIP8 (Zrt- and Irt-like protein 8)NAD (Nicotinamide adenine dinucleotide)
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