Drug intelligence / Profile preview

nicotine oral pouch

Development stage
Phase 2
Lead developer
Niconovum
Modality
Small Molecules
Administration
Buccal
01

Overview

The Niconovum nicotine oral pouch (marketed under the brand name Zonnic) is a tobacco-free nicotine replacement therapy (NRT) designed to assist with smoking cessation and relieve acute tobacco withdrawal symptoms. Originally developed by the Swedish pharmaceutical company Niconovum AB (now a subsidiary of British American Tobacco), the product consists of a small, discrete pouch containing flavored nicotine bound to cellulose and food-grade additives. When placed between the lip and gum, nicotine is rapidly absorbed through the buccal mucosa. Nicotine acts as an agonist on nicotinic acetylcholine receptors (nAChRs) in the central and peripheral nervous systems, mimicking the effects of tobacco-derived nicotine to reduce cravings without exposing the user to the harmful combustion products of smoking.

Brand names
Zonnic
Other names
Niconovum nicotine oral pouchnicotine pouch
02

Targets

α3β4 nAChR (α3β4 nicotinic receptor)α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)

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