Drug intelligence / Profile preview

nicotine polacrilex

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Buccal
01

Overview

Nicotine polacrilex is a pharmaceutical formulation in which nicotine is bound to an ion-exchange resin (such as polymethacrylic acid) to facilitate controlled release and absorption through the oral mucosa. It is primarily used in gum and lozenge forms for nicotine replacement therapy (NRT) to aid smoking cessation. The delivery system maximizes the amount of nicotine absorbed by the mouth—about 80–90% of released nicotine—helping reduce withdrawal symptoms and cravings associated with quitting smoking. Common side effects include bad taste, nausea, dyspepsia, stomatitis, dizziness, dry mouth or throat soreness[1][3][5].

Brand names
NicoretteLeader Nicotine PolacrilexNicoreliefThriveNicorette Cinnamon SurgeNicorette Fruit ChillNicorette Mini
Other names
nicotine gumnicotine lozenge
02

Targets

Nicotinic Acetylcholine Receptor

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