Drug intelligence / Profile preview

Niféxine

Development stage: Phase 4
Lead developer: Laboratoires Leurquin Mediolanum
Modality: Small Molecules
Administration: Rectal, Topical

Overview

**Niféxine** is a French prescription fixed-dose rectal cream containing nifedipine 0.3% and lidocaine hydrochloride 1.5%, indicated in adults for relief of pain associated with chronic anal fissure after usual treatment for acute fissure symptoms has failed. Nifedipine, a dihydropyridine calcium-channel blocker, relaxes the internal anal sphincter and improves local blood flow; lidocaine is an amide local anesthetic that provides rapid local analgesia through sodium-channel blockade. ([leurquin-mediolanum.fr](https://leurquin-mediolanum.fr/m%C3%A9dicaments/nifexine/))

Brand names: Niféxine
Other names: nifedipine + lidocaine hydrochloride

Targets

SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)SCN5A (Sodium channel protein type 5 subunit alpha)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)CACNA1D (Voltage-dependent L-type calcium channel subunit alpha-1D)CACNB2 (Voltage-gated calcium channel β2 subunit)

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