nifenazone

Nifenazone is a small molecule, non-steroidal anti-inflammatory drug (NSAID) of the pyrazolone class that was used as an analgesic and anti-inflammatory agent, primarily for rheumatic conditions such as arthritis and musculoskeletal disorders[3][5][7]. Its mechanism of action involves inhibition of cyclooxygenase (COX), leading to decreased synthesis of prostaglandins, which are mediators of inflammation and pain[1][5]. Nifenazone was administered orally and is well absorbed from the gastrointestinal tract. It undergoes hepatic metabolism mainly via CYP1A2 and CYP2C9 enzymes, with renal excretion[5]. Although initially used for mild to moderate pain (including headaches, menstrual pain, dental pain) and inflammatory conditions, it was later found to have limited clinical value in chronic rheumatic disorders due to side effects—especially in patients with known hypersensitivity to related drugs like phenylbutazone or oxyphenbutazone—and has largely fallen out of use[4].

Brand names

NiapyrinNicophezonNifenazon

Other names

nifenazoneNiapyrinNicophezonNifenazon