Drug intelligence / Profile preview

nifuroxazide

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral
01

Overview

Nifuroxazide is an oral nitrofuran antibiotic used primarily for the treatment of colitis and diarrhea, including infectious and traveler's diarrhea. It acts as a broad-spectrum intestinal anti-infective agent by inhibiting bacterial enzymes essential for cellular processes, thereby exerting its antimicrobial effects. In addition to its antibacterial activity, nifuroxazide has demonstrated antiparasitic properties against organisms such as Giardia lamblia, Cryptosporidium parvum, and Schistosoma mansoni. Recent research suggests potential anticancer, anti-inflammatory, antioxidant, and immunomodulatory activities mediated through inhibition of Signal transducer and activator of transcription 3 (STAT3) signaling pathways and other molecular targets (such as NF-kB and TLR4). The drug is administered orally in capsule or suspension form[1][2][3][4][5][6][7].

Brand names
AmbatrolAntinalBacifuraneDiafurylBenolPérabacticelDiaxNifrozidErcefurylErfuzideEndiexEnterofurylPentofurylNifuroksazyd HascoNifuroksazyd PolpharmaTopronEnterovidEskaparEnterocolinTerracolinApazidNifroxidHufafuralNifuralSeptidiaryl
Other names
nifuroxazidenifuroxazidum
02

Targets

ALDH2 (Mitochondrial Aldehyde Dehydrogenase)STAT3 (Signal Transducer and Activator of Transcription 3)ALDH1A1 (Aldehyde dehydrogenase 1 family member A1)

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