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nigella sativa black seed oil
- Development stage
- Preclinical
- Lead developer
- Dr Taufiq Binjemain
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Nigella sativa black seed oil is a natural plant-derived oil extracted from the seeds of *Nigella sativa* (black cumin), a flowering plant native to Eastern Europe, Western Asia, and the Middle East. The oil's primary pharmacologically active constituent is thymoquinone (TQ), which exhibits anti-inflammatory, antioxidant, and anti-tumor properties. Thymoquinone has been shown to inhibit cancer cell proliferation and induce apoptosis by targeting epigenetic regulators, including ubiquitin-like with PHD and RING finger domains 1 (UHRF1), DNA methyltransferase 1 (DNMT1), and histone deacetylase 1 (HDAC1). In clinical research, Nigella sativa black seed oil is being evaluated as part of a 19-item repurposed drug and nutrient protocol (the ReDO protocol) led by Dr. Taufiq Binjemain in Australia for the treatment of various cancers.
- Other names
- black seed oilblack cumin seed oilNigella sativa oilNigella sativa seed oil
02
Targets
DNMT1 (DNA (cytosine-5)-methyltransferase 1)HDAC1 (Histone Deacetylase 1)UHRF1 (Ubiquitin-like containing PHD and RING finger domain 1)
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