Drug intelligence / Profile preview

Nikcell 2

Development stage
Unknown
Lead developer
Kian Immune Cell Company
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous, Intralesional
01

Overview

Nikcell 2 is a haploidentical natural killer (NK) cell therapy developed by Kian Immune Cell Company, specifically targeting neuroblastoma and potentially other metastatic solid tumors. The therapy is derived from healthy, partially HLA-matched (haploidentical) donors and manufactured according to GMP standards. Its mechanism of action relies on the innate ability of NK cells to recognize and eliminate malignant cells through direct cytotoxicity and immune modulation. The development of Nikcell 2 began in 2020 as a collaboration between the Royan Institute and Tehran University of Medical Sciences, and it is currently undergoing Phase 1 clinical evaluation.

Brand names
Nikcell 2Nikcell2Nikcell-2
Other names
haploidentical NK cell therapy

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