nikkomycin z

Nikkomycin Z is a uridine-based nucleoside-peptide antifungal agent that acts as a selective, competitive inhibitor of chitin synthase, an enzyme essential for fungal cell wall biosynthesis. By inhibiting chitin synthase (notably Chs1 and Chs3 in Saccharomyces cerevisiae and all three isozymes in Candida albicans), it disrupts the formation of chitin, leading to compromised fungal cell walls and cell death. Nikkomycin Z was originally discovered from Streptomyces tendae and has been investigated primarily for the treatment of coccidioidomycosis (Valley Fever), with additional activity against other pathogenic fungi such as Aspergillus fumigatus and Batrachochytrium dendrobatidis. It is considered investigational, with clinical trials evaluating its safety, pharmacokinetics, and efficacy—primarily via oral administration[1][2][3][4][5].

Other names

nikkomycin zneopolyoxin Cnikkomycinhuaguamycin