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Ningmitai Capsule
- Development stage
- Phase 4
- Lead developer
- Xintian Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ningmitai Capsule (NMT) is a Traditional Chinese Medicine (TCM) formulation developed by Guiyang Xintian Pharmaceutical for the treatment of urogenital conditions, including chronic prostatitis, chronic pelvic pain syndrome (CP/CPPS), and urinary tract infections. Approved by China's National Medical Products Administration (NMPA) in 2002, the capsule is composed of several botanical ingredients, including *Polygonum capitatum*, *Imperata cylindrica*, and *Forsythia suspensa*. Its mechanism of action involves anti-inflammatory effects, specifically reducing CCL2 secretion through the inhibition of the MAPK pathway and downregulating the NF-kappaB and STAT3 signaling pathways. Clinical evaluations, including Phase 4 trials, have demonstrated its efficacy both as a monotherapy and in combination with alpha-blockers like tamsulosin for improving symptoms of CP/CPPS.
- Brand names
- Ningmitai
- Other names
- Ningmitai Jiaonang
02
Targets
NF-κBMAPK3 (Mitogen-activated protein kinase 1)STAT3 (Signal Transducer and Activator of Transcription 3)CCL2 (C-C motif chemokine 2)
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