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Ninjinyoeito is a traditional Japanese Kampo medicine composed of twelve medicinal herbs, widely used for the treatment of anemia, fatigue, and physical frailty. It is particularly indicated for patients recovering from illness or surgery who exhibit symptoms such as anorexia, night sweats, and cold extremities. The formula's mechanism of action is multi-targeted, involving the stimulation of erythropoiesis to address anemia and the modulation of the ghrelin system to improve appetite and nutritional status. Recent clinical and preclinical research has also highlighted its potential in mitigating sarcopenia and cognitive decline in the elderly by influencing muscle protein synthesis and neuroprotective pathways.
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