Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
nirogacestat + cocktail of CYP specific probe substrates
- Development stage
- Unknown
- Lead developer
- SpringWorks Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Nirogacestat + cocktail of CYP specific probe substrates refers to a drug combination used in a Phase 1 clinical trial conducted by SpringWorks Therapeutics to evaluate the drug-drug interaction potential of nirogacestat. Nirogacestat (brand name OGSIVEO) is an oral, selective, small molecule gamma secretase inhibitor that prevents the cleavage of transmembrane proteins, including Notch and BCMA, which are involved in tumor growth and survival. The cocktail consists of five specific probe substrates: bupropion (CYP2B6), repaglinide (CYP2C8), flurbiprofen (CYP2C9), omeprazole (CYP2C19), and midazolam (CYP3A4). This study was designed to determine if multiple doses of nirogacestat induce these cytochrome P450 enzymes in healthy adult males by measuring the pharmacokinetics of the probe substrates.
- Brand names
- OGSIVEO
- Other names
- nirogacestat + bupropion + repaglinide + flurbiprofen + omeprazole + midazolam
02
Targets
CYP3A4 (Cytochrome P450 3A4)CYP2C19 (Cytochrome P450 2C19)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP1A2 (Cytochrome P450 1A2)GSEC (Gamma-Secretase Complex)CYP2B6 (Cytochrome P450 2B6)CYP2C8 (Cytochrome P450 2C8)
Beyond the preview
Go deeper on nirogacestat + cocktail of CYP specific probe substrates.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on nirogacestat + cocktail of CYP specific probe substrates.