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Niuhuang Shangqing is a traditional Chinese medicine (TCM) formula primarily used to clear heat, detoxify, and dispel wind. It is composed of multiple herbal and mineral ingredients, including artificial cow gallstone (Calculus Bovis), rhubarb, chrysanthemum, and gypsum. The formula is traditionally indicated for symptoms associated with "internal heat" (Shanghuo), such as headaches, dizziness, red eyes, tinnitus, mouth ulcers, toothaches, and constipation. In modern clinical research, it is being investigated for its efficacy in treating inflammatory conditions like acne vulgaris, as evidenced by clinical trials exploring its safety and effectiveness in this patient population.
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