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nizofenone
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Nizofenone is a neuroprotective small molecule drug belonging to the benzophenone class. It protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain) and has been investigated for use in acute neurological conditions such as stroke, traumatic brain injury, and subarachnoid hemorrhage[1][3][4]. Its mechanism of action includes ameliorating various pathophysiologic events during ischemia—such as ATP depletion, lactate accumulation, glutamate release (notably blocking ischemia-induced excessive glutamate release), free fatty acid liberation, edema, and neuronal degeneration[4][6]. Nizofenone also acts as a radical scavenger comparable to vitamin E and inhibits oxygen radical-induced lipid peroxidation[4][6]. Clinical studies have demonstrated its efficacy in preventing delayed ischemic neurologic deficits due to late vasospasm following subarachnoid hemorrhage[4][8].
- Brand names
- EkonalMidafenone
- Other names
- NizofenonaNizofenonum
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