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nizofenone fumarate
- Development stage
- Unknown
- Lead developer
- Mitsubishi Tanabe Pharma
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Nizofenone fumarate is a neuroprotective small molecule originally developed by Yoshitomi Pharmaceutical (now Mitsubishi Tanabe Pharma) under the code Y-9194. It is primarily indicated for the improvement of neurological symptoms and the prevention of cerebral vasospasm following subarachnoid hemorrhage (SAH). The drug acts by inhibiting lipid peroxidation and protecting neuronal membranes from oxidative stress and ischemic injury. While it has been marketed in Japan under the brand name Midron, Chunfeng Pharmaceutical holds a Chinese patent (ZL201110375763.0) for a refining method of the compound, indicating its role in the manufacturing or development of the drug in the Chinese market.
- Brand names
- Midron
- Other names
- nizofenone2'-(2-aminoethyl)-5-chlorobenzophenone fumarate
02
Targets
Reactive oxygen species and lipid peroxyl radicalsTXA2 (Thromboxane A2)
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