NK-MACE

NK-MACE (Natural Killer Microparticles as Cell Engagers) is a material-based therapeutic approach designed to activate natural killer (NK) cells for tumor therapy. It utilizes polymeric micropatches, typically 4-8 μm in diameter, which are surface-modified with antibodies that target NK cell receptors. These micropatches adhere strongly to NK cells, inducing their activation without the need for co-administered cytokines. The activation achieved by NK-MACE is superior to that induced by nanoparticles, highlighting the importance of the micropatch geometry. NK-MACE-bound NK cells maintain viability, exhibit trans-endothelial migration, and demonstrate antitumor activity in vitro. They also activate T cells, macrophages, and dendritic cells. In preclinical models, adoptive transfer of NK-MACE has shown superior antitumor efficacy in a mouse melanoma lung metastasis model compared to unmodified NK cells. This platform offers a simple, scalable, and effective method for enhancing NK cell therapy.