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NKG2D CAR mRNA-engineered NK cells
- Development stage
- Preclinical
- Lead developer
- PersonGen BioTherapeutics
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Gene Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous, Intratumoral, Intracerebroventricular, Intraperitoneal
01
Overview
NKG2D CAR mRNA-engineered NK cells are a form of cell therapy in which natural killer (NK) cells are genetically modified using messenger RNA (mRNA) to express a chimeric antigen receptor (CAR) that targets ligands for the activating receptor NKG2D. This engineering enhances the ability of NK cells to recognize and kill tumor cells expressing NKG2D ligands. The approach is being investigated as an immunotherapy for both hematological malignancies and solid tumors, with preclinical studies showing enhanced anti-tumor activity compared to conventional memory CAR-T cell therapies. Some constructs also coexpress cytokines such as IL-15 to further boost anti-tumor efficacy[1].
- Other names
- NKG2D-CAR-NK cellsNKG-2D-CAR-NK cellsNKG 2D-CAR-NK cellsNKG2D chimeric antigen receptor mRNA-engineered natural killer cellsNKG-2D chimeric antigen receptor mRNA-engineered natural killer cellsNKG 2D chimeric antigen receptor mRNA-engineered natural killer cells
02
Targets
MICB (Major histocompatibility complex class i-related protein B)
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