NLA Nasal Spray

NLA Nasal Spray is a liposomal formulation of the second-generation antihistamine **cetirizine hydrochloride**, developed by **Biolipox AB** for the treatment of **allergic rhinitis**. Intranasal administration of aqueous cetirizine is often associated with local nasal mucosal irritation and an unpleasant bitter taste, which limits its clinical utility in this route. NLA Nasal Spray utilizes a liposomal delivery technology, encapsulating cetirizine in polar lipid liposomes to mitigate these adverse effects while maintaining the drug's potent antihistaminic activity. As a selective **histamine H1 receptor antagonist**, it works by blocking the action of histamine at the receptor site, thereby reducing common symptoms such as sneezing, itching, and nasal congestion. The drug reached Phase 2 clinical development, where it was evaluated for its taste perversion and local tolerance compared to standard aqueous solutions.

Brand names

NLA Nasal Spray

Other names

liposomal cetirizineliposomal cetirizine hydrochloridecetirizine dihydrochloride liposomal formulation