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NM-05

Development stage: Unknown
Lead developer: Full-Life Technologies
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanobodies (VHH) → Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous

Overview

NM-05 is a radiopharmaceutical comprising a camelid-derived single-domain antibody (sdAb) designed to target Fibroblast Activation Protein (FAP). FAP is a cell-surface glycoprotein significantly overexpressed in cancer-associated fibroblasts (CAFs) within the stroma of most epithelial tumors, while showing low expression in healthy adult tissues. This differential expression makes NM-05 a promising candidate for pan-cancer imaging and therapy. Originally developed by NanoMab Technology, the global intellectual property rights for NM-05 were licensed to Full-Life Technologies for further clinical development.

Targets

FAP (Fibroblast activation protein alpha)

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