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Drug intelligence / Profile preview
NMRC-M3V-Ad-PfCA
- Development stage
- Phase 2
- Lead developer
- Precigen
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
**NMRC-M3V-Ad-PfCA** is an investigational multivalent, non-replicating human adenovirus serotype 5 vaccine developed by the Naval Medical Research Center for prevention of *Plasmodium falciparum* malaria. The product combines two recombinant Ad5 vectors: one encoding *P. falciparum* circumsporozoite protein and one encoding apical membrane antigen 1. By expressing these parasite antigens in vaccinated individuals, it is intended to elicit humoral and cellular immune responses against pre-erythrocytic and blood-stage malaria parasites. In a Phase 1/2a controlled human malaria infection study, the vaccine was reported to be safe, well tolerated, and immunogenic, but it did not provide protective efficacy against controlled human malaria infection.
- Other names
- AdPfCANMRC-Multi-antigen Multi-stage Malaria Vaccine-Adenovectored-Plasmodium falciparum CSP and AMA1 antigens
02
Targets
AMA1 (Apical membrane antigen 1)CSP (Circumsporozoite protein)
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