Drug intelligence / Profile preview

NMRC-M3V-D-PfCAT

Development stage: Phase 1
Lead developer: Naval Medical Research Center
Modality: DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

NMRC-M3V-D-PfCAT is an investigational multicomponent plasmid DNA malaria vaccine developed by the Naval Medical Research Center as the DNA-prime component of the D/ChAd63-CAT heterologous prime-boost regimen. The blended vaccine encodes *Plasmodium falciparum* circumsporozoite protein, apical membrane antigen 1, and malaria multiple epitopes fused to thrombospondin-related adhesion protein. It is intended to induce cellular and humoral immune responses against pre-erythrocytic *P. falciparum* stages and was evaluated by intramuscular administration in a completed Phase 1 controlled human malaria infection study in malaria-naive adults. ([biotechhunter.com](https://biotechhunter.com/trials/NCT03341754))

Other names: D-CAT

Targets

CSP (Circumsporozoite protein)AMA1 (Apical membrane antigen 1)

Beyond the preview

Go deeper on NMRC-M3V-D-PfCAT.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on NMRC-M3V-D-PfCAT.

Explore the full profile