NMS-P715 phosphate

NMS-P715 is a potent, selective, and orally bioavailable small molecule inhibitor of Monopolar Spindle 1 (MPS1) kinase, also known as Threonine Tyrosine Kinase (TTK). Developed by Nerviano Medical Sciences, it belongs to a pyrazoloquinazoline chemical class. MPS1 is a critical component of the spindle assembly checkpoint (SAC), which ensures accurate chromosome segregation during mitosis. By inhibiting MPS1, NMS-P715 disrupts the SAC, leading to premature mitotic exit, chromosomal instability, and mitotic catastrophe, which ultimately induces apoptosis in cancer cells. Preclinical studies have demonstrated that NMS-P715 has significant anti-tumor activity in various solid tumor models, including unresectable hepatocellular carcinoma, where it has been shown to inhibit cell growth and induce cellular senescence.

Other names

n-(2,6-diethylphenyl)-8-({4-[4-(dimethylamino)piperidin-1-yl]-2-methoxyphenyl}amino)-1-methyl-4,5-dihydro-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide phosphate