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NMUR modulator
- Development stage
- Preclinical
- Lead developer
- Limm Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
NMUR modulator is a preclinical small molecule program being developed by Limm Therapeutics. The drug candidates are designed to modulate Neuromedin U receptors (NmUR), specifically targeting the neuro-immune axis to reprogram innate lymphoid cells (ILCs). By mimicking or blocking neuronal signals that communicate with ILCs (such as ILC2s), these small molecules aim to treat a variety of conditions including inflammatory disorders, infectious diseases, and metabolic diseases like obesity and type 2 diabetes. The mechanism involves the precise control of immune cell activity through the nervous system, a field Limm Therapeutics refers to as 'neuronal reprogramming of innate lymphoid cells'. Agonists of NMUR1 are typically explored for metabolic indications, while antagonists are investigated for inflammatory conditions.
- Other names
- Neuronal Reprogrammers of Innate Lymphoid CellsNeuromedin U receptor modulators
02
Targets
NMUR2 (Neuromedin-U receptor 2)NMUR1 (NMU receptor 1 / NMUR1)
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