NNC0502-0361

NNC0502-0361 is a **monoclonal antibody** directed against **Gremlin-1** and is characterized as a non-heparin-displacing antibody. Gremlin-1 is a secreted glycoprotein that acts as an antagonist of bone morphogenetic proteins (BMPs), and has been implicated in metabolic and fibrotic diseases. NNC0502-0361 specifically captures heparin-bound Gremlin-1, forming higher-order complexes that may precipitate, differentiating its action from heparin-displacing anti-Gremlin-1 antibodies[3][5]. The compound has been evaluated in preclinical models for its ability to modulate aspects of metabolic dysfunction, including liver enzyme changes, but human clinical development status for specific diseases is not definitively established from current data.

Other names

NNC0502-0361NNC-0502-0361NNC 0502-0361