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NO-modified autologous tumor vaccine
- Development stage
- Preclinical
- Lead developer
- The Lundquist Institute
- Modality
- Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
NO-modified autologous tumor vaccine is an experimental cancer immunotherapy consisting of autologous tumor cells treated with a nitric oxide (NO) donor. The vaccine is prepared by culturing tumor cells (e.g., B16-F0 melanoma) in the presence of a slow-release NO donor, which immuno-sensitizes the cells by regulating apoptosis-related genes and modifying protein structures. The cells are then homogenized into a crude lysate for administration. In preclinical models, this modification has been shown to significantly decrease tumor growth rates and increase survival by promoting a robust therapeutic immune response against cancer cells.
- Other names
- nitric oxide-modified autologous tumor vaccineNO-modified autologous cancer vaccine
02
Targets
MAGEA8 (Melanoma-associated antigen 8)
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