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non-pulsed dendritic cell vaccine-Hospital Clinic of Barcelona-HIV infection
- Development stage
- Unknown
- Lead developer
- Hospital Clínic de Barcelona
- Modality
- Dendritic Cell Vaccines → Immune Effector Cells → Other Cell Types → Cell Therapies
- Administration
- Subcutaneous
01
Overview
The non-pulsed dendritic cell vaccine developed by the Hospital Clinic of Barcelona is an autologous cell-based therapy used as a control or placebo arm in clinical trials for HIV-1 infection, specifically the DCV-2 and DCV-3 studies. It consists of a patient's own monocyte-derived dendritic cells (MD-DCs) that have been extracted and matured in vitro but, unlike the active therapeutic vaccine, are not 'pulsed' or loaded with heat-inactivated autologous HIV-1 virus. In the context of these trials, this intervention serves to isolate the specific immune-stimulating effect of the HIV antigens from the general stimulatory effect of the dendritic cells themselves. The vaccine is typically administered subcutaneously to patients who are on antiretroviral therapy.
- Other names
- non pulsed dendritic cell vaccinenon-pulsed autologous dendritic cellsunpulsed dendritic cell vaccine
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