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non-targeting locked nucleic acid
- Development stage
- Preclinical
- Lead developer
- Vanderbilt University Medical Center
- Modality
- MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
Non-targeting locked nucleic acid (nt-LNA) is an experimental synthetic oligonucleotide therapeutic that acts as an antagonist of Toll-like receptor 8 (TLR8). Developed by researchers at Vanderbilt University Medical Center, nt-LNA is designed to block the activation of TLR8 by microbial small RNAs (msRNAs) which are transported by low-density lipoproteins (LDL). In macrophages, this activation leads to pro-inflammatory polarization and contributes to the progression of atherosclerosis. Preclinical studies in mouse models (*Apoe-/-* and *Ldlr-/-*) have demonstrated that nt-LNA treatment can reduce plaque burden and promote the regression of advanced atherosclerotic lesions, suggesting a potential novel therapeutic approach for cardiovascular disease by targeting the LDL-msRNA-TLR8 axis.
- Other names
- non-targeting LNA
02
Targets
TLR8 (Toll-like receptor 8)
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