non-triclosan containing toothpaste

Non-triclosan containing toothpaste refers to the control or placebo dentifrice used in clinical trials to evaluate the efficacy of antimicrobial agents like triclosan. In a specific study led by the University of Florida (NCT00920569), this toothpaste was used as a comparator against a triclosan-containing formulation (Colgate Total) in patients with type II diabetes and periodontal disease. The study aimed to determine if the addition of triclosan to a standard oral hygiene regimen could further reduce local inflammatory responses and improve metabolic control. As a placebo, this formulation typically contains standard cleaning agents and fluoride but lacks the specific antibacterial properties provided by triclosan.