nor-LAAM

**nor-LAAM** is the primary active N-demethylated metabolite of levomethadyl acetate (LAAM), a long-acting synthetic opioid. nor-LAAM is a potent opioid with activity at the μ-opioid receptor, contributing significantly to the clinical effects of LAAM due to its high potency and extended duration of action. Recent research focuses on formulating nor-LAAM itself as a long-acting injectable treatment for opioid use disorder (OUD). Studies in animal models indicate that nor-LAAM may offer effective suppression of opioid withdrawal and craving behaviors, with the potential for once-monthly dosing. Early-stage development highlights the use of biodegradable microparticle or polymer-based drug delivery systems for sustained release.

Other names

nor-Levo-α-acetylmethadoll-alpha-Acetyl-N-normethadol