Drug intelligence / Profile preview

norepinephrine + L-NAME

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Intravenous, Intraperitoneal
01

Overview

A combination of norepinephrine (a catecholamine vasopressor) and L-NAME (N-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor). This combination is primarily used in research settings to study vascular function, blood pressure regulation, and the interplay between adrenergic and nitric oxide pathways. Norepinephrine acts predominantly on α-adrenergic receptors to increase blood pressure, while L-NAME blocks nitric oxide production, leading to vasoconstriction and hypertension.

Other names
noradrenaline + L-NAME
02

Targets

ADRA1 (Alpha-1 adrenergic receptor family)ADRB1 (β1)NOS1 (nNOS)

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