Drug intelligence / Profile preview

norethindrone + ethinyl estradiol

Development stage
Approved
Lead developer
Roche
Modality
Small Molecules
Administration
Oral
01

Overview

Norethindrone + ethinyl estradiol is a combination oral contraceptive containing two synthetic hormones: norethindrone (a progestin) and ethinyl estradiol (an estrogen). It is primarily used to prevent pregnancy by inhibiting ovulation, altering cervical mucus to impede sperm penetration, and changing the endometrial lining to reduce the likelihood of implantation[2][3][5]. In some formulations, it may also be used for hormone replacement therapy in menopausal women to treat symptoms such as hot flashes and prevent osteoporosis[4][8]. The drug is available under numerous brand names and dosage forms.

Brand names
Loestrin 24 FeLoestrin24 FeLoestrin-24 FeLoestrin Fe 1.5/30Loestrin Fe 1/20Lo Loestrin FeLomedia 24 FeLomedia24 FeLomedia-24 FeLo Minastrin FeEstrostep FeGildess Fe 1.5/30Gildess Fe 1/20Junel Fe 1.5/30Junel Fe 1/20Junel Fe 24Microgestin Fe 1.5/30Microgestin Fe 1/20Minastrin 24 FEMinastrin24 FEMinastrin-24 FETilia FeTriLegest FeBlisovi 24 FEBlisovi24 FEBlisovi-24 FEBlisovi FE 1.5/30Blisovi FE 1/20TaytullaLarin 24 FELarin24 FELarin-24 FELarin FE 1/20Larin FE 1.5/30Melodetta 24 FEMelodetta24 FEMelodetta-24 FEMibelas 24 FEMibelas24 FEMibelas-24 FETarina 24 FETarina24 FETarina-24 FETarina 24 FETarina FE 1/20Merzee[6][1]
Other names
norethindrone and ethinyl estradiol
02

Targets

ESR2 (ERβ)PR (Progesterone receptor)ESR1 (ERα)

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