norethindrone + mestranol

Norethindrone + mestranol is a combination oral contraceptive containing two types of female hormones: a progestin (norethindrone) and an estrogen (mestranol). This combination works primarily by inhibiting ovulation through suppression of the hypothalamic-pituitary-ovarian axis. Norethindrone acts as a synthetic progestational hormone, while mestranol is a synthetic estrogen that must be demethylated to become biologically active. Together, they alter the cervical mucus and endometrial lining to further prevent fertilization and implantation. The primary indication for this drug is contraception; it may also be used in certain cases for menstrual regulation or treatment of hormonal imbalances[1][2][4][7].

Brand names

Necon 1/50Norinyl 1/50Ortho-Novum 1/50

Other names

norethisterone + mestranol