Drug intelligence / Profile preview

norethindrone enanthate

Development stage
Approved
Lead developer
Bayer HealthCare Pharmaceuticals
Modality
Small Molecules
Administration
Intramuscular
01

Overview

Norethindrone enanthate is a synthetic progestogen (progestin) of the 19-nortestosterone group used primarily as a long-acting injectable contraceptive for women. It acts as an agonist of the progesterone receptor, suppressing ovulation and altering cervical mucus and endometrial lining to prevent pregnancy. Norethindrone enanthate is the C17β enanthate ester of norethisterone (norethindrone), making it a derivative of testosterone with modifications that enhance its progestogenic activity and duration. It was first introduced by Schering in 1957 under the brand name Noristerat and was notable as the first progestogen-only injectable contraceptive[2][4].

Brand names
Noristerat
Other names
norethisterone enanthate17α-ethynyl-19-nortestosterone 17β-enanthate17α-ethynylestr-4-en-17β-ol-3-one 17β-enanthatenorethinyltestosterone enanthate
02

Targets

ER (Estrogen receptor)PR (Progesterone receptor)

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