norethisterone

Ethistron is a pharmaceutical product developed and marketed by Rowez Life Sciences, containing the active ingredient norethisterone (also known as norethindrone). Norethisterone is a potent, synthetic progestin belonging to the 19-nortestosterone family. It functions primarily as an agonist at the progesterone receptor, mimicking the physiological effects of endogenous progesterone. By activating these receptors in the hypothalamus and pituitary gland, it inhibits the secretion of gonadotropins, thereby preventing ovulation. In the uterus, it transforms a proliferative endometrium into a secretory one and, at higher doses, can treat endometriosis by inducing decidualization and subsequent atrophy of endometrial tissue. Ethistron is typically indicated for the management of various gynecological conditions, including abnormal uterine bleeding, primary and secondary amenorrhea, and endometriosis.

Brand names

Ethistron

Other names

Norethindrone17alpha-ethynyl-19-nortestosterone