Drug intelligence / Profile preview

Norflurane

Development stage
Unknown
Lead developer
Chiesi
Modality
Small Molecules
Administration
Inhalation, Topical
01

Overview

Norflurane (1,1,1,2-tetrafluoroethane) is a colorless gas with a slight ethereal odor that is commercially available as a liquid in pressurized cylinders or cans. It is primarily used as a propellant in metered dose inhalers (MDIs) for delivering medications such as salbutamol and salmeterol. Norflurane has also been investigated for use as an inhalational anesthetic agent in animal studies and has been studied clinically as a vapocoolant spray for numbing small boils before incision and drainage. Its mechanism of action does not involve direct pharmacological activity on human targets; rather, it acts physically to deliver drugs or provide local cooling/anaesthesia. Norflurane is rapidly absorbed after inhalation and mainly eliminated by exhalation without significant metabolism[2][3][6][7].

Brand names
Dymel 134ADymel134ADymel-134AForane 134AForane134AForane-134AGenetron 134AGenetron134AGenetron-134ASolkane 134ASolkane134ASolkane-134ASuva 134ASuva134ASuva-134A
Other names
norfluranetetrafluoroethane1,1,1,2-tetrafluoroethane

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