norisoboldine

Norisoboldine is a natural isoquinoline alkaloid and the primary active constituent derived from the dry root of *Lindera aggregata* (Radix Linderae). It is recognized for its potent anti-inflammatory and immunomodulatory properties, particularly in the context of autoimmune diseases. Norisoboldine acts as an aryl hydrocarbon receptor (AhR) agonist, which promotes the differentiation of regulatory T (Treg) cells while inhibiting the development of pro-inflammatory Th17 cells. Additionally, it has been shown to alleviate psoriasis-like symptoms by selectively down-regulating glutaminolysis in γδT17 cells, thereby reducing levels of α-ketoglutarate and subsequent IL-17 production. Research primarily focuses on its potential therapeutic applications for rheumatoid arthritis, ulcerative colitis, and inflammatory skin conditions.

Other names

(S)-Norisoboldine9-methoxy-1,10-dimethyl-6,7-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-8-ol