normal saline + Hyruan

normal saline + Hyruan is a combination therapy consisting of normal saline (0.9% sodium chloride) and Hyruan (a brand of sodium hyaluronate), administered via intra-articular injection. In clinical research conducted by Taipei Medical University, this combination was utilized as a control and comparative arm to evaluate the therapeutic efficacy of adding agents such as triamcinolone or dextrose to a standard hyaluronic acid regimen for knee osteoarthritis. Hyruan functions as a viscosupplement, restoring the viscoelastic properties of the synovial fluid to provide lubrication, reduce friction, and improve shock absorption within the joint. The normal saline component serves as a neutral diluent or volume-matched placebo in the context of clinical trials. Beyond mechanical effects, the hyaluronic acid component interacts with cellular receptors like CD44 to modulate inflammatory responses and support chondrocyte health.

Brand names

Hyruan

Other names

normal saline plus hyruansodium chloride + sodium hyaluronatesaline + hyaluronic acid