Drug intelligence / Profile preview

normal saline + naloxone

Development stage
Unknown
Lead developer
Emergent BioSolutions
Modality
Small Molecules
Administration
Intravenous
01

Overview

This is a combination of two components: - **Normal saline** (0.9% sodium chloride solution) is an isotonic intravenous fluid commonly used for fluid resuscitation, dilution of medications, and as a vehicle for intravenous drug administration. - **Naloxone** is an opioid receptor antagonist used to rapidly reverse the effects of opioid overdose. It works by competitively binding to μ-opioid receptors, displacing opioids and reversing their effects such as respiratory depression and sedation[1][2][5][6][8]. The combination "normal saline + naloxone" refers to naloxone diluted in normal saline for intravenous infusion or injection, which allows titration of dose and controlled administration in emergency settings[5]. This preparation is not a unique branded product but rather a standard clinical practice for delivering naloxone intravenously.

02

Targets

DOR (Opioid Receptor Delta 1)MOR (Mu opioid receptor)KOR (Kappa opioid receptor)

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