Drug intelligence / Profile preview

normal saline + triamcinolone

Development stage
Unknown
Lead developer
Hikma Pharmaceuticals
Modality
Small Molecules
Administration
Intralesional, Intramuscular, Intraarticular, Intrabursal, Intrasynovial
01

Overview

This is a combination of normal saline (an isotonic sodium chloride solution) and triamcinolone, a synthetic glucocorticoid corticosteroid. The mixture is typically prepared by diluting triamcinolone with normal saline to achieve the desired concentration for injection. Triamcinolone acts as an anti-inflammatory and immunosuppressive agent by binding to glucocorticoid receptors, modulating gene expression, and suppressing the production of pro-inflammatory mediators. Normal saline serves as a diluent to adjust the steroid concentration for safe administration, particularly in intralesional or intramuscular injections. This combination is used in various dermatological and musculoskeletal conditions such as seborrheic dermatitis, keloids, hypertrophic scars, arthritis, tendonitis, and other inflammatory disorders[1][2]. The dilution allows for tailored dosing based on lesion size or clinical indication.

02

Targets

GR (Glucocorticoid receptor)

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